Session Time: 11:15am-12:45pm
Location: Research Hub - Kiosk 8
Disclosures: Jillian K. Price, PhD: Nothing to disclose
Objective: This study assesses the association of orosomucoid (ORM), a glycoprotein that is an acute-phase protein that promotes glycogen accumulation in muscles thus involved in energy balance regulation with physical performance, and self-reports of activity level and fatigue in patients with non-alcoholic liver disease (NAFLD).
Design: Determination of presence of an analyte in a population with/without NAFLD
Participants: Research subjects with and without NAFLD
Main Outcome Measures: Concentration of ORM in serum
Results: The cohort of 50 subjects [64% NAFLD, age: 42.8±14.8 years, 56% female, 58% Caucasian, BMI: 30.2±5.4, 12% metabolic syndrome, resting VO2: 3.6±1.1 mL/kg/min, VO2 Peak: 28.8±10.0 mL/kg/min, resting heart rate: 80±15, heart rate max: 159±22 bpm, Human Activity Profile (HAP), maximal activity score (MAS): 84±10, HAP adjusted activity score(AAS): 81±12, Fatigue Severity Score (FSS): 3.2±1.4] was included in analysis. ORM levels were higher in NAFLD versus non-NAFLD subjects (77.1±3.4 and 74.0±1.3, respectively, P=.01). ORM correlated negatively with AAS (r=0.398; P=.024) and resting VO2 (r=0.295; P=.04). ORM and FSS were not found to be associated.
Conclusions: Higher ORM levels were associated with NAFLD presence. ORM levels were negatively correlated with daily activity levels and resting VO2, but not correlated with self-reported fatigue. These findings suggest that the concentration of ORM distinguishes people with NAFLD from those without NAFLD. These preliminary findings suggest ORM may have clinical relevance as a biomarker because when elevated, it is associated with people who have low levels of self-reported physical activity as well as a low resting VO2.
Level of Evidence: Level III
To cite this abstract in AMA style:Price JK, Mehta R, Austin P, Escheik C, Gerber L, Younossi Z. Orosomucoid (ORM) Is Associated with Decreased Daily Activity Level and Resting O2 Volume [abstract]. PM R. 2019; 11(S2)(suppl 2). https://pmrjabstracts.org/abstract/orosomucoid-orm-is-associated-with-decreased-daily-activity-level-and-resting-o2-volume/. Accessed December 3, 2023.
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