Disclosures: Jillian K. Price, PhD: Nothing to disclose

Objective: This study assesses the association of orosomucoid (ORM), a glycoprotein that is an acute-phase protein that promotes glycogen accumulation in muscles thus involved in energy balance regulation with physical performance, and self-reports of activity level and fatigue in patients with non-alcoholic liver disease (NAFLD).

Design: Determination of presence of an analyte in a population with/without NAFLD

Setting: Laboratory

Participants: Research subjects with and without NAFLD

Interventions: N/A

Main Outcome Measures: Concentration of ORM in serum

Results: The cohort of 50 subjects [64% NAFLD, age: 42.8±14.8 years, 56% female, 58% Caucasian, BMI: 30.2±5.4, 12% metabolic syndrome, resting VO₂: 3.6±1.1 mL/kg/min, VO₂ Peak: 28.8±10.0 mL/kg/min, resting heart rate: 80±15, heart rate max: 159±22 bpm, Human Activity Profile (HAP), maximal activity score (MAS): 84±10, HAP adjusted activity score(AAS): 81±12, Fatigue Severity Score (FSS): 3.2±1.4] was included in analysis. ORM levels were higher in NAFLD versus non-NAFLD subjects (77.1±3.4 and 74.0±1.3, respectively, P=.01). ORM correlated negatively with AAS (r=0.398; P=.024) and resting VO₂ (r=0.295; P=.04). ORM and FSS were not found to be associated.

Conclusions: Higher ORM levels were associated with NAFLD presence. ORM levels were negatively correlated with daily activity levels and resting VO₂, but not correlated with self-reported fatigue. These findings suggest that the concentration of ORM distinguishes people with NAFLD from those without NAFLD. These preliminary findings suggest ORM may have clinical relevance as a biomarker because when elevated, it is associated with people who have low levels of self-reported physical activity as well as a low resting VO₂.

Level of Evidence: Level III

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PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/orosomucoid-orm-is-associated-with-decreased-daily-activity-level-and-resting-o2-volume/