Disclosures: Tahsin Ashraf, DO: Nothing to disclose

Objective: Accessing the effect of repetitive transcranial magnetic stimulation on motor/cognitive function following acute ischemic strokes.

Design: Case-control study

Setting: Rehabilitation unit in tertiary hospital.

Participants: 10 patients with recent acute ischemic stroke admitted to acute rehabilitation.

Interventions: Subjects received rTMS stimulation to the left dorsolateral prefrontal cortex (DLPFC) for 5 consecutive weekdays. Treatment consisted of 120% magnetic field intensity relative to the MT at 10Hz, 10 pulse per second, with a stimulus duration of 4 seconds and intertrain interval of 26 seconds.

Main Outcome Measures: MOCA, Boston Naming test, Fugl-Meyer upper extremity, Becks Depression inventory, and Hamilton Rating Scale for Depression were completed prior to and after the intervention.

Results: On Hamilton Rating Scale, patients scored an average of 6.00. Post treatment, patients scored an average of 3.25 with a deviation 2.67 showing significant improvement (P= .007). On Beck’s Depression inventory, patients scored an average of 10.08 and post-treatment, patients scored an average of 6.58 with a deviation of 4.72 which shows a significant improvement (P= .009). On Fugl-Meyer, patients scored an average of 10.70. Post-treatment patients scored an average of 20.30 and an average deviation of 21.03 which shows improvement significantly from baseline (P= .03). On MOCA, patients scored an average of 19.76 and after treatment an average of 21.75 with a deviation of 4.88 demonstrating significant improvement (P= .009). On the Boston naming task, patients scored an average of 12.67 and after treatment they scored an average of 13.25 with a deviation of 2.63. T test analysis shows that there was no difference in patient’s naming ability after baseline (P= .131).

Conclusions: Improvement was seen in motor and cognitive areas following rTMS. rTMS is a feasible treatment for acute ischemic stroke resulting in hemiplegia that can be used in acute inpatient rehabilitation along with therapy; however further research is needed in this area including controls.

Level of Evidence: Level III

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PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/assessing-the-effect-of-repetitive-transcranial-magnetic-stimulation-rtms-after-acute-ischemic-stroke-case-control-study/