Session Information
Session Title: Research Spotlight: Musculoskeletal and Sports Medicine
Session Time: None. Available on demand.
Disclosures: Anuj Marathe, BBA: No financial relationships or conflicts of interest
Objective: Platelet Rich Plasma (PRP) has been extensively utilized as a therapy for many musculoskeletal diseases. Despite its broad use clinically, there is still an unmet need in standardizing PRP formulations, specifically among two main formulations, Leukocyte Rich PRP (LR-PRP) and Leukocyte Poor PRP (LP-PRP). One critical step towards standardizing PRP is to comprehensively characterize participating cell types in PRP, namely with respect to leukocyte composition.
Design: Prospective Human Ex-Vivo AnalysisSetting : Controlled Laboratory StudyParticipants : 12 healthy adult males between ages 25 to 31
Interventions: not applicable
Main Outcome Measures: Leukocyte Profile in Human LR-PRP
Results: In LR-PRP, lymphocytes were the predominant WBC type (11.94 ± 2.97 x 103 cells/μL) followed by neutrophils (3.72 ± 1.28 x 103 cells/μL). The mean cumulative percentage of granulocytes was 25% ± 8% and agranulocytes was 75% ± 9%. There was a significant difference observed between granulocyte and agranulocyte percentage within both WB and LR-PRP groups. In addition, there was a significant difference observed between the WB and LR-PRP granulocyte percentages and between the WB and LR-PRP agranulocyte percentages.Conclusions: LR-PRP is predominantly lymphocyte rich but contains other WBC sub-types that are not currently reported which could affect LR-PRP’s therapeutic efficacy.
Level of Evidence: Level V
To cite this abstract in AMA style:
Marathe A, Jayaram P, Song B, Patel SJ. A Comprehensive Characterization of Leukocyte Rich Platelet Rich Plasma: A Controlled Laboratory Study [abstract]. PM R. 2021; 13(S1)(suppl 1). https://pmrjabstracts.org/abstract/a-comprehensive-characterization-of-leukocyte-rich-platelet-rich-plasma-a-controlled-laboratory-study/. Accessed October 8, 2024.« Back to AAPM&R Annual Assembly 2021
PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/a-comprehensive-characterization-of-leukocyte-rich-platelet-rich-plasma-a-controlled-laboratory-study/