Session Information
Date: Friday, November 15, 2019
Session Title: Research Spotlight: Musculoskeletal and Sports Medicine
Session Time: 11:00am-11:45am
Location: Research Hub - Live Theater
Disclosures: Michael R Baria, MD, FAAPMR: Arthrex (Research Grant or Support)
Objective: To determine the effect of high intensity interval training on platelet-rich plasma composition.
Design: Controlled Laboratory Study
Setting: Academic Sports Medicine Clinic / Comparative Orthopedics Laboratory
Participants: 5 men, 5 women, healthy with no major medical problems including inflammatory disease, cardiopulmonary problems or orthopedic conditions that would prevent participation in exercise.
Interventions: All subjects had a 15-mL blood draw to create PRP using the Arthrex ACP system. Immediately after the first PRP preparation, all subjects underwent a monitored exercise protocol that consisted of a 5-minute warm-up, followed by the original protocol described by Dr. Izumi Tabata (20-second sprint, 10-second rest for 4 minutes on a Schwinn AirDyne). Subjects were allowed to recover for up to 5 minutes. Then a second blood draw was performed to create post-exercise PRP. All PRP created was sent to the laboratory for analysis.
Main Outcome Measures: Pre-exercise and post-exercise PRP was examined for differences in platelet count, leukocyte count, differential, red cell count and mean platelet volume using an automated hemo-analyzer.
Results: Average age of participants was 39.6 ± 9.8 years with a range of 28 to 60. Average time to completion of the blood draw was 4 minutes and 36 seconds with a standard deviation of 21.5 seconds. Platelet count increased from 367.4 ± 57.5 to 497.7 ± 93.3 (P value .000). Mean platelet volume (fL) increased from 7.9 ± 0.6 to 8.3 ± 1.0 (P value .013). Red blood cells increased from 0.21 ± 0.16 to 0.30 ± 0.16 (P value .019). White blood cells increased from 2.4 ± 1.2 to 6.1 ± 4.5 (P value .010) All cell counts are presented in values of 1000/uL.
Conclusions: A brief 4-minute protocol of high intensity interval exercise is able to increase platelet yield in PRP. Further research is needed to determine if this increased cell count improves clinical outcomes.
Level of Evidence: Level III
To cite this abstract in AMA style:
Baria MR, Desmond S. The Effect of High Intensity Interval Training on Platelet-rich Plasma Composition [abstract]. PM R. 2019; 11(S2)(suppl 2). https://pmrjabstracts.org/abstract/the-effect-of-high-intensity-interval-training-on-platelet-rich-plasma-composition/. Accessed May 15, 2025.« Back to AAPM&R Annual Assembly 2019
PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/the-effect-of-high-intensity-interval-training-on-platelet-rich-plasma-composition/