Disclosures: Heather K. Vincent, PhD, MS, FACSM: Medicine and Science in Sports and Exercise (Products/Services: No) (Officer or Board Member)

Background and/or Objectives: To determine the effect of bodyweight cycling on clinical symptoms, physical function and depression scores over six years compared to stable or unidirectional trajectories of bodyweight change in patients with knee osteoarthritis.

Design: Secondary data analysis using the Osteoarthritis Initiative.

Setting: Academic medical center.

Participants: Participants were classified into 7 groups based on temporal change patterns of body mass index (BMI), assessed biannually, over a six-year period (N&#3f730) as follows: 1) stable low (BMI < 25 kg/m2), 2) stable overweight (BMI=25-29.9 kg/m2), and 3) stable obese (BMI ≥30kg/m2); 4) steady weight loss (weight loss ≥2.2kg every 2-years), and 5) steady weight gain (weight gain ≥2.2kg every 2-years), at each timepoint; and 6) gain-loss-gain and 7) loss-gain-loss, where bodyweight changed by ≥2.2 kg with return to at least that same bodyweight two years later.

Interventions: Not applicable

Main Outcome Measures: Knee Injury and Osteoarthritis Outcome Score (KOOS); Physical Activity in the Elderly (PASE); Short Form SF-12 Physical Function; chair rise test; 20-meter walk; Center for Epidemiological Studies Depression (CESD) scale.

Results: The steady weight loss group demonstrated the worst knee pain, chair rise times, gait speed, PASE subscores, KOOS Function in Sports and Recreation, and the highest CESD scores over time (p’s

Conclusions: Weight cycling of either pattern in middle-to-older age did not consistently and adversely affect outcomes. However, steady weight loss in this population was associated with worse outcomes and highest depression severity over six years. Steady weight loss in middle-to-older age individuals may be counteracted with consistent participation in muscle strengthening activities.

Level of Evidence: Level II

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PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/six-year-weight-cycling-effects-on-knee-pain-physical-function-and-depression-in-adults-with-knee-osteoarthritis/