Disclosures: Qianfeng Li, MD: No financial relationships or conflicts of interest
Objective: To explore utility of Neurofilaments light chain(NfL) as a biomarker for acute and chronic post-stroke fatigue.
Design: A retrospective clinical pilot study. Setting : Acute PSF inpatient rehabilitation facility and Chronic PSF outpatient training. Participants : Including 36 acute stroke patients and 30 chronic stroke patients.
Interventions: All subjects received standard physical therapy, occupational thearpy and speech therapy.
Main Outcome Measures: Acute and chronic stroke groups were classified into two fatigue groups based on Fatigue Pictogram (FP) and Fatigue Severity Scale, independently.The serum level of Neurofilament light chain (NF-L) was measured using single-molecule array (Simoa HD-1 Analyzer). Mann-Whitney test was used to compare NfL level between two fatigue groups. Pearson correlation test was performed to analyze covariates. Chi-square was used to analysis categorical variables.
Results: There was a significant difference of NF-L level between acute stroke and chronic stroke group (Z=-6.478, p < 0.01, 474.03(251.65, 1193.42) VS 17.88(11.60, 72.12). Besides, there was a significant difference of NF-L level between mild fatigue group and moderate/ to severe fatigue group (Z=-2.519, p=0.012, 318.59(188.81, 500.01) VS 710.93(382.39, 1737.30)) in acute stroke patients and positive correlation between FP and the level of NfL(r=0.450, p=0.006) in acute stroke patients. However, there was no significant different in NfL level between mild fatigue and moderate/severe fatigue group in chronic stroke patients. Conclusions: Our preliminary findings suggest that the level of serum NF-L has different association with acute and chronic post-stroke fatigue, indicating acute and chronic post-stroke fatigue may have has different biological mechanisms.
Level of Evidence: Level III
To cite this abstract in AMA style:
Li Q, Zhang Y, Luo X, Wang Q. Pilot Study, Different Association of Neurofilaments Light Chain with Acute and Chronic Post-Stroke Fatigue [abstract]. PM R. 2020; 12(S1)(suppl 1). https://pmrjabstracts.org/abstract/pilot-study-different-association-of-neurofilaments-light-chain-with-acute-and-chronic-post-stroke-fatigue/. Accessed June 28, 2025.« Back to AAPM&R Annual Assembly 2020
PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/pilot-study-different-association-of-neurofilaments-light-chain-with-acute-and-chronic-post-stroke-fatigue/