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Pediatric Neuropathic Pain: A Review of the Literature

Faheem Mahomed, MD (University of Texas Health Science Center San Antonio Long SOM PM&R Program, San Antonio, TX, United States); Caroline P. Brennick, DO; Nicholas Fleming, DO

Meeting: AAPM&R Annual Assembly 2019

Session Information

Date: Saturday, November 16, 2019

Session Title: Pediatrics Case Report

Session Time: 11:15am-12:45pm

Location: Research Hub - Kiosk 3

Disclosures: Faheem Mahomed, MD: Nothing to disclose

Objective: To provide a comprehensive and thorough review of the existing literature with regards to the identification/management of neuropathic pain in the pediatric population. Specifically, to provide an updated and concise analysis of the current pharmacological, interventional, and alternative modalities of treatment of neuropathic pain in the pediatric population.

Design: An exhaustive literature review of the relevant published works was complete. Our literature review was conducted using PubMed, OVID, and Google Scholar databases. Over 400 articles were reviewed (after exclusion criteria applied). Searches were conducted using the following key words: ‘Pediatric,’ ‘Neuropathic Pain,’ ‘Neuralgia,’ ‘Therapy, ‘Diet Therapy,’ ‘Drug Therapy,’ ‘Rehabilitation’. Articles were excluded based on pre-determined criteria (i.e. written in English, availability of full text, age 0-18, date of article publication, level of evidence rating).

Setting: Our literature review was conducted with the assistance of the University of Texas Long School of Medicine Health Sciences Library and the Children’s Hospital of San Antonio (CHOSA) Pediatric Rehabilitation Department.

Participants: This literature review surveyed over 400 articles (after exclusion criteria applied), which included, but was not limited to various case reports, randomized controlled trials, systematic reviews, retrospective cohort studies, and case series.

Interventions: Several treatment modalities/interventions were studied throughout this literature review. These included pharmacologic therapies, diet therapy, surgical procedures, as well as physical treatment modalities and rehabilitation.

Main Outcome Measures: General and overall recommendations for treatment of neuropathic pain in the pediatric population were generated and organized within our review based on overall level of evidence rating of the treatment modalities studied in each of the surveyed articles.

Results: Through conduction of this literature review we were able to devise an up to date collection of guidelines regarding identification, management, and treatment of neuropathic pain in the pediatric population.

Conclusions: Current pediatric neuropathic pain treatments and management/identification strategies were identified and these are outlined within our literature review.

Level of Evidence: Level V

To cite this abstract in AMA style:

Mahomed F, Brennick CP, Fleming N. Pediatric Neuropathic Pain: A Review of the Literature [abstract]. PM R. 2019; 11(S2)(suppl 2). https://pmrjabstracts.org/abstract/pediatric-neuropathic-pain-a-review-of-the-literature/. Accessed May 12, 2025.
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