Disclosures: So Young Lee, MD: No financial relationships or conflicts of interest

Objective: to investigate the prevalence of osteosarcopenia and its impact on physical function, quality of life and pain in patients with end-stage knee osteoarthritis

Design: A cross-sectional study Setting : A rehabilitation facility at university hospital Participants : We assessed a total of 578 patients (77 males and 501 females) who were diagnosed with end-stage knee osteoarthritis (OA)

Interventions: Not applicable

Main Outcome Measures: We divided patient into four groups according to the presence of osteoporosis and sarcopenia(defined as a loss of skeletal muscle mass by Bioelectrical Impedance Analysis). The concept of osteosarcopenia is defined as patients with osteoporosis and sarcopenia. All patients completed performance-based physical function tests including stair climbing test (SCT), 6-minute walk test (6MWT), timed up and go test (TUG), instrumental gait analysis for spatio-temporal parameters. Self-reported physical function and pain were measured using the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS), and self-reported quality of life was measured using the EuroQOL five dimensions (EQ-5D) questionnaire.

Results: Osteoporosis alone was diagnosed in 191 subjects (33%), sarcopenia alone in 23 (4%), and osteosarcopenia in 13 (2.2%). Among 13 patients with osteosarcopenia, 11(84.6) were females and 2(15.4) were males. In the analysis of variance (ANOVA), osteosarcopenia group exhibited significantly higher scores in SCT-ascent, SCT-descent, TUG, and lower scores in 6MWT, gait speed, cadence and EQ-5D in other groups (P < 0.05). After adjusting for age, sex, BMI by the logistic regression, SCT-descent (β=0.158, p < 0.001, R2=0.13), SCT-descent (β=0.169, p < 0.001, R2=0.118), 6MWT (β=0.091, p=0.027, R2=0.027), TUG (β=0.14, p=0.001, R2=0.128), EQ-5D (β=-0.14, p=0.001, R2=0.033), WOMAC pain(β=0.158, p < 0.001, R2=0.13), gait speed (β=-0.138, p=0.001, R2=0.085) and cadence (β=-0.131, p=0.002, R2=0.039) were significantly associated with patients with osteosarcopenia (OR=1.040, 95% CI 1.010-1.071, p=0.010) Conclusions: This study confirmed the prevalence of osteosarcopenia could be associated with the performance-based and self-reported physical function, and quality of life in patients with end-stage knee OA

Level of Evidence: Level II

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PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/epidemiology-and-effect-on-physical-function-of-osteosarcopenia-in-patients-with-end-stage-knee-osteoarthritis/