Disclosures: Elver S. Ho: Bionano Genomics (Products/Services: No) (Stockholder/Ownership Interest (excluding diversified mutual funds))Senseonics (Products/Services: No) (Stockholder/Ownership Interest (excluding diversified mutual funds))

Background and/or Objectives: The Template for Intervention Description and Replication (TiDieR) checklist assesses reporting quality of interventions to improve results interpretation and scientific reproducibility. The TiDieR Checklist consists of 12 items: Name, Rationale, Materials, Procedure, Provider, Mode-of-Delivery, Setting, Dosage, Tailoring, Modifications, How-Well-Planned, and How-Well-Actual. Traumatic brain injury (TBI) is a form of acquired brain injury that can result in long-term functional impairment. To date, no study has assessed the reporting quality of rehabilitative interventions for TBI randomized controlled trials (RCT).

Design: A systematic review of the rehabilitation literature on TBI RCTs was performed using the TiDieR checklist. PubMed, Embase, and Cochrane were queried for peer-reviewed RCTs studying TBI interventions from years 2015 to 2021. After screening, control and experimental intervention groups of each article were scored (2=fully reported, 1=partially reported, 0=not reported) for adherence to the twelve TiDieR checklist items.

Setting: Systematic review.

Participants: 823 articles were identified. 120 RCTs were scored, yielding 120 control and 132 experimental interventions.

Interventions: Analysis of published research.

Main Outcome Measures: Level of adherence to TiDieR checklist items and effect of journal impact factor on adherence level to TiDieR checklist.

Results: Experimental intervention groups had higher rates of complete reporting for rationale (99.2% vs 95.0%, p=0.034), materials (92.4% vs 67.5%, p < 0.001), procedure (92.4% vs 80.0%, p < 0.001), provider (55.3% vs 44.2%, p < 0.001), mode-of-delivery (52.3% vs 41.7%, p < 0.001), setting (50.0% vs 43.3%, p=0.019), and dosage (90.2% vs 75.0%, p < 0.001). Composite TiDieR scores did not correlate with journal impact factor for control (r=0.052, p=0.611) or experimental interventions (r=0.043, p=0.671).

Conclusions: Peer-reviewed RCTs for TBI rehabilitation interventions were moderately adherent to the TiDieR checklist with control interventions having lower rates of full reporting in rationale, materials, procedure, provider, mode-of-delivery, setting and dosage items. Future TBI intervention studies should consider incorporating the TiDieR checklist for improved clinical reproducibility and potential impact on health outcomes of TBI patients.

Level of Evidence: Level II

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PM&R Meeting Abstracts - https://pmrjabstracts.org/abstract/assessing-the-quality-of-traumatic-brain-injury-interventions-reporting-using-the-template-for-intervention-description-and-replication-checklist/